If you’re checking through your mail logs, or you catch a bounced e-mail with “554 relay access denied” in the bounce, the issue can be related to a few different things:
If you find that Horde (with Plesk) keeps refreshing when you attempt to log in, and there are no errors logged on the screen or in Apache’s logs, check the session.
Often times, the wonderful webmail application known as Horde will spin out of control and cause unnecessary resource usage and often cause defunct Apache processes to appear.
If Plesk ever appears to be out of sync with the configuration files, or if there’s a Plesk issue that’s occurring that makes no sense at all, just stand back and wave the Plesk magic wand: